| The Radiation Sensitizer Effect of TNF-α on Heterotransplanted Human Squamous Cell Carcinoma |
|
Phil Sang Chung;Han Gyun Kim;Hyong Geun Yun |
| 이종이식된 인체 편평상피세포암에 대한 종양괴사인자의 방사선감작효과에 대한 연구 |
|
정필상;김한균;윤형근 |
|
|
|
|
| Abstract |
Background and Objectives: Numerous studies were conducted to develop radiosensitizers to increase antitumor effect and decrease systemic toxicity of ionizing radiation. In current study, the authors tested the synergistic effect of mutant TNF−α(M3S) with radiation therapy on heterotransplanted hypoparyngeal squamous cell carcinoma.
Materials and Method: SNU-1041 cell line was heterotransplanted to nude mice. When the tumors grew up to 70mm(3) or more, the animals were randomly placed into 4 groups(n=10/group). Group I : 0.1ml of normal saline injected intraperitoneally once a day for 5 days. Group II : 10ug of TNF-α injected intraperitoneally once a day for 5 days. Group III : a single radiation dose of 10 Gy per animal delivered. Group IV : single radiation dose of 10 Gy was delivered 1 hour after intraperitoneal injection of TNF-α 10 ug.
Results
Four weeks after treatment, group IV showed the least tumor growth during the 4 weeks follow up and the relative tumor growth rate(RTG) of each groups after 4 weeks were 31, 5.8, 10, and 3.2 respectively(p<0.05).
Conclusion
These study suggests that pretreatment with TNF-α can significantly enhance the effects of radiation therapy and further studies may be needed for clinical trials of combination treatment of TNF-α and radiation. |
| Key Words:
TNF-α, Radiosensitizer, Squamous cell carcinoma |
|
PDF Links
Full text via DOI
Download Citation
