| The Expression of Epidermal Growth Factor Receptor in Thyroid Diseases |
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Byoung Chul Min;Yong Jin Lee;Seong Jae Cha;Yong Kum Park;Kyung Chun Chi;Hyun Muck Lim;Sung Il Park;Sung Jun Park |
| 갑상선 질환에서 표피성장인자 수용체 발현 |
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민병철;이용진;차성재;박용검;지경천;임현묵;박성일;박성준 |
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| Abstract |
Objectives: The epidermal growth factor receptor(EGFR) family has been increasingly recognized as an important component in the control of normal cell proliferation and the pathogenesis of cancer. To confirm the usefulness of epidermal growth factor receptor as a tumor marker, we initiated this study.
Materials and Methods: EGFR was measured by immunohistochemical staining using EGFR antibody. It was performed on section from paraffin blocks of 65 thyroid tissue including 33 paillary carcinoma, 11 follicular carcinoma, 11 nodular hyperplasia, 5 follicular adenoma and 5 normal thyroid tissue. We evaluated morphologic characteristic of various thyroid neoplasms, and the relationship between EGFR and other prognostic factors in papillary thyroid carcinomas.
Results
The expression of EGFR was commonly found in neoplasms of thyroid, with trend for stronger staining in the more malignant tumor(p=0.000). Also the expression of EGFR in papillary thyroid cancer related to tumor characters including tumor size(p=0.042), extent(p=0.024) and prognostic features including AMES scores(p=0.019). The strong EGFR staining in papillary carcinoma was significantly associated with tumor recurrence(p=0.003).
Conclusions
EGFR may have a role in the regulation of normal and neoplastic thyroid cell growth. EGFR status may help predict the clinical course of patients with malignant thyroid neoplasms. However, the study of more cases will be needed for significance of the information about the EGFR as an independent prognostic factor. |
| Key Words:
Epidermal growth factor receptor, Thyroid disease |
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