| Neoadjuvant Chemotherapy and Radiotherapy for the Treatment of Advanced Hypopharyngeal Carcinoma |
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Hyo Jeong Lee;Myung Whun Sung;Bum Jung Park;Myung Chul Lee;Woo Sub Sim;Weon Jin Seong;Jong Lyel Roh;Kwang Hyun Kim |
| 진행성 하인두암에서 선행화학요법과 방사선요법 |
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이효정;성명훈;박범정;이명철;심우섭;성원진;노종렬;김광현 |
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| Abstract |
Background and Objectives: To evaluate the efficacy of the neoadjuvant chemotherapy and radiation therapy in treatment of patients with advanced hypopharyngeal cancer, which is notorious for its poor prognosis and severe surgical morbidity with functional deficits.
Materials and Methods: Medical records and radiologic findings of 107 patients with squamous cell carcinoma of the hypopharynx, Stage III or IV (AJCC, 1997), were retrospectively reviewed.
Results
Neoadjuvant chemotherapy followed by radiation therapy showed 74% complete remission (CR) rate. The patients who did not show CR after chemotherapy had a high likelihood of treatment failure, even though they achieved CR following subsequent radiotherapy. Twenty-eight of 57 patients were able to preserve their larynges for more than three years by chemotherapy and radiation.
Conclusions
This approach appeared to be as effective as radical surgery with postoperative radiation therapy without comprising of survival. To improve the cure rates, we need to develop better strategies to increase CR rates with chemotherapy and determine the best treatment option for patients who are partially or nonresponsive to chemotherapy. |
| Key Words:
Hypopharyngeal carcinoma, Neoadjuvant chemotherapy, Radiotherapy |
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