XPC-PAT Polymorphism in Korean Thyroid Papillary Carcinoma

Korean Journal of Head & Neck Oncology 2006;22(2):117-122.
Published online November 30, 2006.

Kyung Tae;Keun Young Lee;Hee Ok Kim;Yong Seop Lee;Hyung Seok Lee;You Hern Ahn

한국인 갑상선 유두상암종 환자에서 XPC-PAT 유전자 다형

태경;이근영;김희옥;이용섭;이형석;안유헌

Abstract

Background and Objectives ：Thyroid carcinoma is the sixth commonest cancer in Korea and the papillary carcinoma is the most common type(88%) of the malignant thyroid tumors. Bulky DNA adducts formed by the carcinogens are repaired by DNA repair process, but failure to repair this DNA damage can cause mutations in oncogenes and tumor suppressor genes resulting in tumor formation. The xeroderma pigmentosum group C ( XPC ) gene is essential for this repair procedure and the XPC-PolyAT ( PAT ) polymorphisms may alter DNA repair capacity(DRC) and genetic susceptibility to cancer. Subjects and Methods ：In a case-control study of 113 Korean patients with pathologically diagnosed thyroid papillary carcinoma and 65 control subjects, we investigated the association between the three XPC-PAT gene polymorphisms and thyroid papillary cancer susceptibility.
Results
：The frequency of the variant XPC-PAT allele was lower in the cases(0.349) than in the controls (0.423), but the difference was not significant(p=0.140). Using logistic regression adjusting for age and sex, risk for thyroid papillary cancer was not increased in the XPC-PAT -/+ and XPC-PAT +/+ compared to XPC-PAT -/- (adjusted overall odds ratio[95% confidence intervals ； 95%CI]=0.52[0.26-1.03] and 0.62 [0.22-1.75], respectively; trend test, p=0.167). Conclusion ：There are no relationship between the XPC-PAT polymorphism and the risk of thyroid papillary carcinoma in Korean population. Based on our results, XPC-PAT polymorphism do not modulate genetic susceptibility to thyroid papillary cancer.

Key Words: Thyroid cancer, Xeroderma pigmentosum group C(XPC), Polymorphisms, XPC-PAT.