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Korean Journal of Head & Neck Oncology 2007;23(2):153-156.
Published online November 30, 2007.
A Case of Pharmacokinetics of Cisplatin in Concurrent Chemoradiation for Hemodialysis Patient with Advanced Head and Neck Cancer
Younjoo Jeon;ByoungYong Shim;Hyung Wook Kim;Sang-Hun Lee:이호상;Ho-Sang Lee;heol Whee Park;Suzy Kim;Hyo-Jeong Kuh;Hoon-Kyo Kim
혈액 투석을 받는 두경부암 환자의 동시화학방사선요법에서 Cisplatin의 약력학 조사 1예
전연주;심병용;김형욱;이상훈;박철휘;김수지;구효정;김훈교
Abstract
Objectives :We study the feasibility and pharmacokinetics of cisplatin concurrent chemoradiation for ad-vanced head and neck cancer patient undergoing hemodialysis. Materials and Methods :A 57-year old male with end stage renal disease developed stage III external auditory canal cancer. Complete resection surgery was done. Postoperative 6 months, local recurrence was occurred. De-spite excision and adjuvant radiotherapy, local tumor was recurred. We decided to treat a cisplatin concurrent chemoradiotherapy. Cisplatin was administered at a dose of 20mg/m 2 for 30 min. Hemodialysis was started 30 min after completion of the cisplatin infusion and performed for 4 hours. Hemodialysis was performed on day 3 and 5 of chemotherapy. Plasma samples were collected at specified times after administration of cisplatin. Result :At the end of the third cycle of cisplatin concurrent chemoradiotherapy, the tumor size was mark-edly decreased. The maximum plasma concentrations of plasma platinum and free platinum were 0.74 and 0.37μg/ml respectively. The area under the curve of plasma platinum and free platinum were 94.7 and 11.3μg·h/ml respectively.
Conclusion
:We report a case of Cisplatin concurrent chemoradiation for hemodialysis patient with advanced head and neck cancer and suggest full dose cisplatin concurrent chemoradiotherpay is tolerable for these patients
Key Words: Pharmacokinetics, Cisplatin, Head and neck cancer, Hemodialysis, Cisplatin


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