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Korean Journal of Head & Neck Oncology 2011;27(1):3-11.
Published online May 30, 2011.
Analysis of (-)-Epigallocatechin-3-Gallate-Induced Apoptosis and Inhibition of Invasiveness in Oral Cavity Carcinoma Squamous Cell Carcinoma According to Expression of c-Met
Yoo Seob Shin;Yoon Woo Koh;, Eun Chang Choi;Sung Un Kang;Hye Sook Hwang;Oak-Sung Choo;Han Bin Lee;Chul-Ho Kim
구강암편평세포암에서 c-Met 발현여부에 따른 (-)-Epigallocatechin-3-Gallate의 세포사멸 및 종양침습억제효과의 변화분석
신유섭;고윤우;최은창;강성운;황혜숙;추옥성;이한빈;김철호
Abstract
Hepatocyte growth factor(HGF) and c-Met play an important role in the control of tumor growth and inva-sion, and they are known to be good prognostic indicators of patient outcome. Epigallocatechin-3-gallate (EGCG) has been shown to have chemopreventive and therapeutic properties by modulating multiple signal pathways regarding the control of proliferation and invasion of cells. In this study, we evaluated the role of c-Met in EGCG-induced inhibition of invasion and apoptosis in an oral cancer cell line. In KB cells where c-Met was knocked down with siRNA, we performed invasion assay and FACS with Annexin V-FITC/PT staining. In addition, we checked the change of mitochondrial membrane potential(MMP) and the generation of reactive ox-ygen species(ROS). EGCG-induced inhibition of invasiveness was significantly decreased after the knock-down of c-Met. EGCG-induced apoptosis, MMP change and ROS generation was also reduced in c-Met knock-ed-down KB cells. These results suggest that c-Met is involved in EGCG-induced apoptosis and inhibition of invasiveness of oral cancer cell line.
Key Words: HGF(Hepatocyte Growth Factor), c-Met, EGCG, Oral cavity cancer, Apoptosis, Invasion, c-Met
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