Tumor Interstitial Fluid Pressure in Patients with Head and Neck Cancer |
Moon June Cho;Jae Sung Kim;ln tae Lee;Jun Sang Kim;Ji Young Jang;Ki Hwan Kim |
두경부 악성 종양 조직내 간질액 압력 |
조문준;김재성;이인태;김준상;장지영;김기환 |
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Abstract |
Objectives: To determine the tumor interstitial fluid pressure(TIFP) in patients with head and neck cancerand predict radiotherapy outcome.
Materials and Methods: In 12 biopsy proven primary head and neck cancer patients with accessible by direct inspection and palpation, and of sufficient thickness(>1cm) to permit accurate needle placement, we measured TIFP at cervical lymph node before and during radiotherapy using a modified wick-in-needle technique. Tumor size was measured clinically and radiologically.
Results The mean preradiotherapy TIFP was 23.4mmHg. Preradiotherapy TIFP had significant relationship with tumor size(p=0.0009). Preradiotherapy TIFP was not different between complete response group and partial or less response group(p=0.114). Radiotherapy outcome was not different between group with above and group with below average TIFP(p=0.09).
Conclusion The mean TIFP was elevated with 23.4mmHg before radiation therapy. Preradiotherapy TIFP had significant relationship with tumor size. It is not definitive that TIFP could be prognostic indicator of radiation response. |
Key Words:
Tumor interstitial fluid pressure, Head and neck cancer, Radiotherapy |
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